Abstract:

The recent development of intensity modulated radiation therapy (IMRT) allows radiation dose distribution to be tailored to match the tumor�s shape and position avoiding damage to healthy tissue to a greater extent than previously possible. We propose a robust formulation for IMRT treatment planning problem that incorporates intrinsic geometric uncertainties into the model. The approach has the potential to find treatment plans that are more adept at sparing healthy tissue while maintaining the prescribed dose to the target as compared to traditional models. Several strategies to address computational challenges arising in robust IMRT treatment planning will be discussed..