Speaker:   Lucian Ilie
  Department of Computer Science
  University of Western Ontario


Title:  HiTEC: accurate error correction in high-throughput DNA sequencing data

High-throughput, or next generation, DNA sequencing technologies produce very large amounts of data and sequencing errors constitute one of the major problems in its analysis. Current algorithms for correcting these errors are not very accurate and do not automatically adapt to the given data. We present HiTEC, an algorithm that provides a highly accurate, robust and fully automated method to correct reads produced by high-throughput sequencing methods. Our approach provides significantly higher accuracy than competing methods. It is time and space efficient and works very well for all read lengths, genome sizes and coverage levels. The source code of HiTEC is freely available at www.csd.uwo.ca/~ilie/HiTEC/. The talk will include also a brief introduction to next generation sequencing techniques.